The convergence of laboratory medicine, novel whole-slide imaging technologies, and the availability of cloud storage has created a unique opportunity for patient care. At Mayo Clinic, state-of-the-art scanning facilities support the extensive digitization of pathology slides. The clinic’s robust infrastructure integrates AI for real-time quality control, ensuring high accuracy in digitizing archived tissue slides. By empowering pathologists without coding experience to develop their own algorithms with user-friendly tools, Mayo Clinic fosters inclusivity in innovation. The future of digital pathology at Mayo Clinic is multimodal. AI-driven mutation prediction algorithms and immersive VR environments designed for pathologists, by pathologists, may significantly enhance diagnostic precision, efficiency, and collaboration within the medical community.